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DOI:http://dx.doi.org/10.26855/ijcemr.2019.10.001

Anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim against lipopolysaccharides-induced acute lung injury mice

Author: Ruixue Yu, Lei Jiang, Lijuan Mei, Yanduo Tao, Ruitao Yu, Xichao Xia
Date: October 18,2019 Hits: 171

Abstract

OBJECTIVE: To investigate the anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim on acute lung injury of mice.
METHODS: Animals were randomly divided six groups (n=15) including normal group, model group, control group (Dex group), low-dose group of SM, middle-dose group of SM and high-dose group of SM. Ear oedema was induced by xylene and oedematous response was measured. Leukocyte, TNF-α and COX-2 level of blood was determined. Histological changes of lung were examined by hematoxylin and eosin.
RESULTS: Compared with that of normal group, levels of right ear oedema decreased 46.17% and 50.92% in middle-dose group of SM and high-dose group of SM, respectively. Compared with that of model group, quantity of leukocyte reduced 47.32% (P<0.05), 56.20% (P<0.05) and 49.47% (P<0.05) at 1h, 6h and 12h in the high-dose group of SM, respectively. In the high-dose group of SM, the level of TNF-α reduced 85.47% (P<0.05) and 73.74% (P<0.05) at 6 h and 12 h compared with that of model group, respectively. In the high-dose group of SM, the level of COX-2 reduced 37.69% (P<0.05) at 12 h in contrasted with that of model group. Injury of lungs were attenuated by different-dose of alcohol extract from S. medusa treatment.
CONCLUSION: The alcohol extract from S. medusa can play a protecting-role against lung injury in acute lung injury mice maybe through decreasing leukocyte, TNF-α and COX-2 level and enhancing the anti-inflammatory effects.

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Anti-inflammatory effects of alcohol extract from Saussurea  medusa Maxim against lipopolysaccharides-induced acute lung injury mice
Ruixue Yu
Pingdingshan University, Pingdingshan 467000, China
Lei Jiang
Key Laboratory of Tibetan Medicine Research; Qinghai Provincial Key Laboratory of Tibetan Medicine
Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences. Xining 810008,China
Lijuan Mei
Key Laboratory of Tibetan Medicine Research; Qinghai Provincial Key Laboratory of Tibetan Medicine
Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences. Xining 810008,China
Yanduo Tao
Key Laboratory of Tibetan Medicine Research; Qinghai Provincial Key Laboratory of Tibetan Medicine
Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences. Xining 810008,China
Ruitao Yu
Key Laboratory of Tibetan Medicine Research; Qinghai Provincial Key Laboratory of Tibetan Medicine
Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences. Xining 810008,China
Xichao Xia
Pingdingshan University, Pingdingshan 467000, China
How to cite this paper: Ruixue Yu, Lei Jiang, Lijuan Mei, Yanduo Tao, Ruitao Yu, Xichao Xia.(2019) Anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim against lipopolysaccharides-induced acute lung injury mice. International Journal of Clinical and Experimental Medicine Research, 3(4), 112-118.
DOI: 10.26855/ijcemr.2019.10.001

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