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Anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim against lipopolysaccharides-induced acute lung injury mice

Date: October 18,2019 |Hits: 852 Download PDF How to cite this paper

Ruixue Yu 1,†, Lei Jiang 2,†, Lijuan Mei 2, Yanduo Tao 2, Ruitao Yu 2,*, Xichao Xia 1,*

1 Pingdingshan University, Pingdingshan 467000, China.

2 Key Laboratory of Tibetan Medicine Research; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences. Xining 810008,China.

These authors contributed equally to this work.

*Corresponding author: Ruitao Yu, Xichao Xia.


OBJECTIVE: To investigate the anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim on acute lung injury of mice.

METHODS: Animals were randomly divided six groups (n=15) including normal group, model group, control group (Dex group), low-dose group of SM, middle-dose group of SM and high-dose group of SM. Ear oedema was induced by xylene and oedematous response was measured. Leukocyte, TNF-α and COX-2 level of blood was determined. Histological changes of lung were examined by hematoxylin and eosin.

RESULTS: Compared with that of normal group, levels of right ear oedema decreased 46.17% and 50.92% in middle-dose group of SM and high-dose group of SM, respectively. Compared with that of model group, quantity of leukocyte reduced 47.32% (P<0.05), 56.20% (P<0.05) and 49.47% (P<0.05) at 1h, 6h and 12h in the high-dose group of SM, respectively. In the high-dose group of SM, the level of TNF-α reduced 85.47% (P<0.05) and 73.74% (P<0.05) at 6 h and 12 h compared with that of model group, respectively. In the high-dose group of SM, the level of COX-2 reduced 37.69% (P<0.05) at 12 h in contrasted with that of model group. Injury of lungs were attenuated by different-dose of alcohol extract from S. medusa treatment.

CONCLUSION: The alcohol extract from S. medusa can play a protecting-role against lung injury in acute lung injury mice maybe through decreasing leukocyte, TNF-α and COX-2 level and enhancing the anti-inflammatory effects.


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How to cite this paper

Anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim against lipopolysaccharides-induced acute lung injury mice

How to cite this paper: Ruixue Yu, Lei Jiang, Lijuan Mei, Yanduo Tao, Ruitao Yu, Xichao Xia.(2019) Anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim against lipopolysaccharides-induced acute lung injury mice. International Journal of Clinical and Experimental Medicine Research, 3(4), 112-118.

DOI: http://dx.doi.org/10.26855/ijcemr.2019.10.001

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