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DOI:http://dx.doi.org/10.26855/ijcemr.2020.04.005

Genetic polymorphism of DNATyper X19 kit in Northern Chinese Han people

YU Zhengliang1, CAI Huiju1, MA Wenhua1, MO Xiaoting1, YAO Yiren1, WANG Le1, LIU Chao2, ZHAO Xingchun1, LI Wanshui1,*

1Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China.

2Guangzhou Forensic Institute, Guangzhou 510000, China.

*Corresponding author: LI WanshuiInstitute of Forensic Science, Ministry of Public Security, Beijing 100038, China.

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Date: May 7,2020 Hits: 319, How to cite this paper

Abstract

Objective. To evaluate the value of DNATyper X19 kit in the forensic application. Methods. In this study, we carried out a survey of genetic polymorphism from 374 Northern Chinese Han individuals. Results. A total of 140 alleles were detected among the 18 X-STR loci from 374 Northern Chinese Han individuals, 228 haplotypes were detected from the 228 males, the diversity is 100%. No markers departed from Hardy-Weinberg equilibrium after applying Bonferroni’s correction for multiple testing (p=0.05/18), GATA31E08-DXS6797, DXS8377-DXS10079 were in linkage disequilibrium (LD) in this study (p=0.05/153). The polymorphism information content (PIC) was 0.434-0.908 and the discrimination power (DP) was 0.432-0.983. The combined discrimination power was 0.99999993 for male and 0.999999992 for female. The combined mean exclusion chance was 0.999993 in duo cases (CMECduo) and 0.999999994 in trio case (CMECtrio). Conclusions. DNATyper X19 kit showed potential value for complicated paternity cases.

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Genetic polymorphism of DNATyper X19 kit in Northern Chinese Han people

How to cite this paper: YU Zhengliang, CAI Huiju, MA Wenhua, MO Xiaoting, YAO Yiren, WANG Le, LIU Chao, ZHAO Xingchun, LI Wanshui. (2020Genetic polymorphism of DNATyper X19 kit in Northern Chinese Han people. International Journal of Clinical and Experimental Medicine Research, 4(2), 28-33.

DOI: http://dx.doi.org/10.26855/ijcemr.2020.04.005


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