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DOI:http://dx.doi.org/10.26855/ijcemr.2020.10.009

Mechanism of Sanren Decoction in Treating Constipation Based on Network Pharmacology

Guo Zihua1,*, Cui Yaping1, Bi Chuan chuan2, Xiao Xia2, Jiang Hua2

1Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, China.

2Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712000, China.

*Corresponding author: Guo Zihua

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Date: September 10,2020 Hits: 122, How to cite this paper

Abstract

Objective: To analyze the potential mechanism of Sanren Decoction in the treatment of constipation by using network pharmacological methods, and to provide a theoretical reference for further experimental research. Methods: The TCMSP, Uniprot, and Genecards databases were searched, and the targets of Sanren Tang chemical constituents and constipation-related targets were screened. Cytoscape software was used to construct the chemical composi-tion-target-disease network of Sanren Tang. The biological function and signal pathway were analyzed to explore the mechanism of Sanren Decoction in the treatment of constipation. Results: According to the screening conditions [oral bioavailability (OB) ≥ 30, drug-like (DL) ≥ 0.18)], a total of 502 active ingredients and 219 potential drug targets were obtained. A total of 2,842 disease targets were collected in the Genecards database and the UniProt database with “constipation” as the search condition 119 core target proteins of Sanren Decoction for constipation were screened, which mainly involved DRD1, CHRM3, CHRM1, PTGS2, RXRA and so on. The main biological processes of GO include: ubiquitin-like protein ligase binding, kinase-regulated activity, cytokine receptor binding, ubiquitin-protein ligase binding, and protein kinase regulator activity. KEGG enrichment results mainly include: PI3K-Akt signaling pathway, hepatitis B pathway, human cytomegalovirus infection pathway, hepatitis C pathway, Kaposi’s sarcoma-associated herpes virus infection pathway, and so on. Conclusion: The mechanism of Sanren Decoction in the treatment of constipation may be related to its multiple components acting on multiple targets, affecting multiple signal pathways related to constipation, and regulating complex biological processes.

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Full-Text HTML

Mechanism of Sanren Decoction in Treating Constipation Based on Network Pharmacology
How to cite this paper: Guo Zihua, Cui Yaping, Bi Chuan chuan, Xiao Xia, Jiang Hua. (2020Mechanism of Sanren Decoction in Treating Constipation Based on Network PharmacologyInternational Journal of Clinical and Experimental Medicine Research, 4(4), 175-181.

DOI: http://dx.doi.org/10.26855/ijcemr.2020.10.009

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