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Mucoadhesive Microsphere Drug Delivery System (MMDDS): A Mini Review

Date: September 9,2021 |Hits: 377 Download PDF How to cite this paper

Srilatha Malvey1,*, A. Kottai Muthu2, K. Balamurugan2, J. Venkteshwar Rao1, Goverdhan Puchchakayala3, E. Ravinder4, Naresh Kshirasagar5

1Talla Padmavathi College of Pharmacy, Kareemabad Warangal, Telangana, India.

2Annamalai University, FEAT, Annamalainagar, Tamilnadu, India.

3Department of Pharmacological and Pharmaceutical Science, University of Houston, Houston, Texas, USA.

4Vaagdevi College of Pharmacy, Hanamkonda, Telangana State, India.

5Sree Dattha Institute of Pharmaceutical Science, Ibrahimpatnam, RR District, Telangana, India.

*Corresponding author: Srilatha Malvey


Over the past few decades, broad research work has been carried out to develop a gastro-retentive dosage form, this type of dosage form shows effectiveness in delivery of drug due to its presence in the stomach for enough time. The present survey is concern about the review of bioadhesive or mucoadhesive microspheres, for its combined effect of bioadhesion and surface to volume ratio of microspheres in which particle size is range from 1-1,000 µm range in diameter having a core of drug and outer layer of mucoadhesive polymer. Mucoadhesive microspheres have advantage of controlled and sustained release of drug from dosage form with less fluctuation in blood concentration. Evaluation of Mucoadhesive Microspheres has to be carried for FTIR Studies, Scanning Electron Microscopy (SEM), Micrometric Studies, Bulk Density, Tapped Density, Angle of Repose, % Compressibility Index, Hausner’s Ratio, Particle Size, Density Determination, Floating Behavior, Angle of Contact, Swelling Index, Percentage Yield, Percentage Drug Content, The Percentage of Drug Entrapment, Drug Entrapment Efficiency, Ex Vitro Mucoadhesive Study, In Vitro Drug Release Studies, In Vivo X-Ray Imaging Study, In Vitro Wash-Off Test for Microspheres, Mucoadhesive Microspheres Stability in the pH 1.0 HCl Medium, Stability Studies. The present review highlights some of the new drugs that can be benefits from MMDDS.


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How to cite this paper

Mucoadhesive Microsphere Drug Delivery System (MMDDS): A Mini Review

How to cite this paper: Srilatha Malvey, A. Kottai Muthu, K. Balamurugan, J. Venkteshwar Rao, Goverdhan Puchchakayala, E. Ravinder, Naresh Kshirasagar. (2021) Mucoadhesive Microsphere Drug Delivery System (MMDDS): A Mini Review. International Journal of Clinical and Experimental Medicine Research5(4), 435-444.

DOI: http://dx.doi.org/10.26855/ijcemr.2021.10.003

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