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Associations among Lipid Profile, Mucin1 and Cholesterol Ester Transfer Protein Status in Bangladeshi Patients with Cholelithiasis and Effects of Laparoscopic Cholecystectomy on Them

Date: July 18,2022 |Hits: 312 Download PDF How to cite this paper

Abu S. M. Giasuddin1,*, Khadija A. Jhuma2, Mohammad A. M. Chowdhury3, Abu M. M. Haq4

1Professor of Biochemistry & Immunology & Director of Medical Research Unit (MRU), Medical & Health Welfare Trust (MHWT), Medical College for Women and Hospital (MCW&H), Plot-4 Road-8/9 Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh. 

2Professor & Head of Department (HOD) at Department of Biochemistry & Molecular Biology, MCW&H& Member Secretary of MRU, MHWT, Plot-4, Road-8/9, Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh.

3Associate Professor of Surgery, Department of Surgery, MCW&H, MHWT, Plot-4, Road-8/9, Sector-1, Uttara Model Town, Dha-ka-1230, Bangladesh.

4Honorary Professor of Internal Medicine, Department of Medicine, MCW&H and Chairman of MRU, MHWT, Plot-4, Road-8/9, Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh.

*Corresponding author: Abu S. M. Giasuddin


Objectives: To evaluate associations among Lipid Profile, Mucin1 CETP status between adult normal control subjects (NCs) and cholelithiasis i.e. gallstone disease (GSD) patients (Pts) preoperatively (I0) and postoperatively (II0) with laparoscopic cholecystectomy. Patients and Methods: Adult Pts with GSD (N=55, Gender: 10 males, 45 females; Age range: 28-60 years, Mean age ± SD: 45.5±12.2 years) and NCs (N: 40, Gender: 16 males, 24 females, Mean age + SD: 42.5+10.5 Years) were those reported in our previous case-control prospective interventional studies carried out from October 2016 to March 2018 at MRU, MHWT, Uttara, Dhaka, Bangladesh. Serum lipid profile (TG, TC, LDL-C, HDL-C), Lp(a), ApoA1, ApoB100, ApoE, Mucin1 and CETP status in NCs (I0) and Pts (I0, II0) were reported in the recent past. Further advanced statistical analyses on these data were made according to the objectives of the present article as stated above regarding associations (correlations) among these staus by using SPSS programme-version 26. Results: About associations among the Lipid Profile and Mucin1 status between NCs (I0) and Pts (I0, II0), significant Pearson correlations were found for Pts-TG (Serum-I0) vs Pts-TG (Serum-II0) (r=0.545, p=0.001), Pts-TC (Serum-I0) vs Pts-TC (Serum-II0) (r=0.385, p=0.025) and Pts-LDL-C (Serum-I0) vs Pts-LDL-C (Serum-II0) (r=0.393, p=0.022). No significant associations (correlations) were obtained for HDL-C among the groups compared (p>0.05). Although significant association (correlation) was obtained for Pts-Mucin1 (Serum-I0) vs Pts-Mucin1 (Serum-II0) (r=0.766, p=0.000), no significant associations (correlations) were found for TG vs Mucin1 status and TC vs Mucin1 status for any of the groups compared (p>0.05). However, significant associations were shown for Pts LDL-C (Serum-I0) vs Pts Mucin1 (Serum-II0) (r=0.381, p=0.026), Pts-HDL-C (Serum-I0) vs Pts-Mucin1 (Serum-II0) (r=0.475, p=0.005) and NCs-HDL-C (Serum-I0) vs Pts-Mucin1 (Bile-I0) (r=0.419, p=0.026) respectively. Regarding associations for TG and CETP status between NCs, Pts (I0) and Pts (II0), no significant correlations were noted for any of the groups compared. About associations for TC levels between NCs and Pts, significant correlation was obtained for Pts-TC (Bile-I0) vs Pts-CETP (Serum-II0) only (r=0.384, p=0.045). Associations for LDL-C vs CETP between NCs and Pts, showed no significant correlations for any of the groups compared (p>0.05). But significant Pearson correlation was obtained for Pts-HDL-C (Bile-I0) vs Pts-CETP (Serum-II0) (r=0.388, p=0.023) only. However, no associations were noted for CETP levels for any of the NCs and Pts groups compared (p>0.05). Conclusions: These results on associations (correlations) among the parameters between NCs and Pts (I0, II0) suggested involvements of TG, TC and LDL-C in the disease process and probable interactions of LDL-C and Mucin1 and HDL-C and CETP in the aetiopathogenesis of the disease. These findings were discussed in the light of recent knowledge available on molecular mechanisms for the pathogenesis of GSD i.e. cholelithiasis.


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How to cite this paper

Associations among Lipid Profile, Mucin1 and Cholesterol Ester Transfer Protein Status in Bangladeshi Patients with Cholelithiasis and Effects of Laparoscopic Cholecystectomy on Them

How to cite this paper: Abu S. M. Giasuddin, Khadija A. Jhuma, Mohammad A. M. Chowdhury, Abu M. M. Haq. (2022) Associations among Lipid Profile, Mucin1 and Cholesterol Ester Transfer Protein Status in Bangladeshi Patients with Cholelithiasis and Effects of Laparoscopic Cholecystectomy on Them. International Journal of Clinical and Experimental Medicine Research6(3), 275-285.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.07.008

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