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Research Progress of Chronic Wounds

Date: August 1,2022 |Hits: 1820 Download PDF How to cite this paper

Lizhen Dai1, Hongtao Xiong2,*

1Department of Hand Surgery, Longgang District Orthopedic Hospital, Shenzhen, Guangdong, Shenzhen 518116, Guangdong, China. 

2Department of Hand and Microvascular Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.

*Corresponding author: Hongtao Xiong


The vast majority of wounds progress unrestrictedly through normal wound healing processes (hemostasis, inflammation, proliferation, remodeling). However, a large proportion of people fail to progress through these steps, resulting in chronic wounds with associated morbidity and costs. How to deal with chronic wounds has become a hot topic in clinical research, and the definition of chronic wounds is still controversial. A retrospective analysis of past clinical cases and literature reviews, the evaluation of the diagnosis and treatment of chronic wounds, and the key points of diagnosis and treatment at the emerging stage. Chronic wounds are commonly divided into: diabetic foot ulcers, pressure ulcers, venous ulcers, and ischemic ulcers. More medical data are still needed to provide more effective options for the diagnosis and treatment of chronic wounds. Currently, treatment is based on the TIME (tissue debridement, infection/inflammation management, water balance, and wound edge) concept. This ensures proper treatment is given. The vast majority of wounds are likely best treated with simple treatment and regular debridement.


[1] Greeley, P. W. (1953). Plastic surgical closure of chronic open wounds of the leg [J]. Ind Med Surg, 1953, 22(1): 22-3.

[2] Carleson, R., Garsten, P. (1952). Wound therapy with septofyllin, with special consideration of its effect on chronic leg ulcers [J]. Nord Med, 1952, 47(13): 412-6.

[3] Cazander, G., Pritchard, D. I., Nigam, Y., et al. (2013). Multiple actions of Lucilia sericata larvae in hard-to-heal wounds: larval secretions contain molecul es that accelerate wound healing, reduce chronic inflammation and inhibit bacterial infection [J]. Bioessays, 2013, 35(12): 1083-92.

[4] Nunan, R., Harding, K. G., Martin, P. (2014). Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their co mplexity [J]. Dis Model Mech, 2014, 7(11): 1205-13.

[5] Dubhashi, S. P., Sindwani, R. D. (2015). A Comparative Study of Honey and Phenytoin Dressings for Chronic Wounds [J]. Indian J Surg, 2015, 77(Suppl 3): 1209-13.

[6] Leaper, D. J., Durani, P. (2008). Topical antimicrobial therapy of chronic wounds healing by secondary intention using iodine products [J]. Int Wound J, 2008, 5(2): 361-8.

[7] Kyaw, B. M., JRbrink, K., Martinengo, L., et al. (2018). Need for Improved Definition of “Chronic Wounds” in Clinical Studies [J]. Acta Derm Venereol, 2018, 98(1): 157-158.

[8] Demidova-Rice, T. N., Hamblin, M. R., Herman, I. M. (2012). Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: nor mal and chronic wounds: biology, causes, and approaches to care [J]. Adv Skin Wound Care, 2012, 25(7): 304-14.

[9] Morton, L. M., Phillips, T. J. (2016). Wound healing and treating wounds: Differential diagnosis and evaluation of chronic wounds [J]. J Am Acad Dermatol, 2016, 74(4): 589-605; quiz 605-6.

[10] Velnar, T., Bailey, T., Smrkolj, V. (2009). The wound healing process: an overview of the cellular and molecular mechanisms [J]. J Int Med Res, 2009, 37(5): 1528-42.

[11] Tsourdi, E., Barthel, A., Rietzsch, H., et al. (2013). Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus [J]. Biomed Res Int, 2013: 385641.

[12] Reinke, J. M., Sorg, H. (2012). Wound repair and regeneration [J]. Eur Surg Res, 2012, 49(1): 35-43.

[13] Mast, B. A., Schultz, G. S. (1996). Interactions of cytokines, growth factors, and proteases in acute and chronic wounds [J]. Wound Repair Regen, 1996, 4(4): 411-20.

[14] Satish, L. (2015). Chemokines as Therapeutic Targets to Improve Healing Efficiency of Chronic Wounds [J]. Adv Wound Care (New Rochelle), 2015, 4(11): 651-659.

[15] Everett, E., Mathioudakis, N. (2018). Update on management of diabetic foot ulcers [J]. Ann N Y Acad Sci, 2018, 1411(1): 153-165.

[16] Dealey, C., Brindle, C. T., Black, J., et al. (2015). Challenges in pressure ulcer prevention [J]. Int Wound J, 2015, 12(3): 309-12.

[17] Vivas, A., Lev-Tov, H., Kirsner, R. S. (2016). Venous Leg Ulcers [J]. Ann Intern Med, 2016, 165(3): Itc17-itc32.

[18] Hoversten, K. P., Kiemele, L. J., Stolp, A. M., et al. (2020). Prevention, Diagnosis, and Management of Chronic Wounds in Older Adults [J]. Mayo Clin Proc, 2020, 95(9): 2021-2034.

[19] Oates, A., Bowling, F. L., Boulton, A. J., et al. (2014). The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy met hods [J]. J Diabetes Res, 2014, 2014: 153586.

[20] Metcalf, D. G., Bowler, P. G., Hurlow, J. (2014). A clinical algorithm for wound biofilm identification [J]. J Wound Care, 2014, 23(3): 137-8, 140-2.

[21] Serena, T. E. (2014). Development of a Novel Technique to Collect Proteases from Chronic Wounds [J]. Adv Wound Care (New Rochelle), 2014, 3(12): 729-732.

[22] Blokhuis-Arkes, M. H., Haalboom, M., Van Der Palen, J., et al. (2015). Rapid enzyme analysis as a diagnostic tool for wound infection: Comparison between clinical judgment, microbiological analysis, and enzyme analysis [J]. Wound Repair Regen, 2015, 23(3): 345-52.

[23] Becerra, S. C., Roy, D. C., Sanchez, C. J., et al. (2016). An optimized staining technique for the detection of Gram positive and Gram negative bacteria within tissue [J]. BMC Res Notes, 2016, 9: 216.

[24] Aldaz, G., Shluzas, L. A., Pickham, D., et al. (2015). Hands-free image capture, data tagging and transfer using Google Glass: a pilot study for improved wo und care management [J]. PLoS One, 2015, 10(4): e0121179.

[25] Taverna, D., Pollins, A. C., Sindona, G., et al. (2015). Imaging mass spectrometry for assessing cutaneous wound healing: analysis of pressure ulcers [J]. J Proteome Res, 2015, 14(2): 986-96.

[26] Hattori, Y., Falgout, L., Lee, W., et al. (2014). Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healin g [J]. Adv Healthc Mater, 2014, 3(10): 1597-607.

[27] Harries, R. L., Bosanquet, D. C., Harding, K. G. (2016). Wound bed preparation: TIME for an update [J]. Int Wound J, 2016, 13 Suppl 3: 8-14.

[28] Sibbald, R. G., Elliott, J. A., Persaud-Jaimangal, R., et al. (2021). Wound Bed Preparation 2021 [J]. Adv Skin Wound Care, 2021, 34(4): 183-195.

[29] Wang Shuhuan. (2011). The third edition of Hand Surgery [M]. Beijing: People’s Health Publishing House, 2011: 812.

How to cite this paper

Research Progress of Chronic Wounds

How to cite this paper: Lizhen Dai, Hongtao Xiong. (2022) Research Progress of Chronic Wounds. International Journal of Clinical and Experimental Medicine Research6(3), 309-313.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.07.012

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