magazinelogo

International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 219189 Total View: 2502905
Frequency: quarterly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2022.10.015

Clinical Study of 566 Cases of Senile Spinal Tuberculosis

Lilan Wu1, Manying Qu1, Zhi Jiang2,*, Ke Wan2

1The Second People's Hospital of Guangdong Province, Guangzhou 510317, Guangdong Province, China.

2Changsha Central Hospital, Changsha 410028, Hunan Province, China.

*Corresponding author: Zhi Jiang

Published: November 15,2022

Abstract

Objective: To summarize the clinical characteristics of 566 patients with senile spinal tuberculosis, and to explore the efficacy and clinical value of paravertebral puncture injection in the treatment of senile spinal tuberculosis. Methods:  The clinical data of 566 elderly patients with spinal tuberculosis were retrospectively analyzed. All patients underwent Mycobacterium tuberculosis smear and culture, T-SPOT test (T-Spot.TB), CT and MRI. Combined with oral anti-tuberculosis drugs for 1.5-2 years. Results: 498 patients (88%) were treated with oral antituberculosis drugs and paravertebral puncture, the clinical symptoms were improved significantly, no pain, tuberculosis poisoning symptoms disappeared, activity limitation disappeared or relieved, and clinical cure was achieved. Sixty-eight patients (12%) with severe limb paraplegia, obvious neurological impairment, spinal instability and other patients who met the indications for surgery underwent debridement and fixation after 2-4 weeks of paravertebral injection. Conclusion: Regular paravertebral puncture and local drug injection is beneficial to improve the cure rate of senile spinal tuberculosis. Compared with surgery, it is more simple, safe and effective. It is suitable for clinical application and can be regarded as a good strategy for conservative treatment in internal medicine.

References

[1] Gilpin C, Korobitsyn A, Migliori GB, et al. The World Health Organization standards for tuberculosis care and management [J]. Eur Respir J, 2018, 51(3):1800098. DOI: 10.1183/13993003.00098-2018.

[2] Bhosale S, Prabhakar A, Srivastava S, et al. Pattern of drug resistance in primary spinal tuberculosis: Global Spine J, 2021, 11 (7): 1070-1075. DOI: 10.1177/2192568220941445.

[3] Jiang Zhi, Liu Bo, Chen Chao, Wan Ke, Qu Manying, Hu Yunfen, Peng Yi. Systemic chemotherapy with CT positioning ver-tebral side curative effect observation of local treatment of spinal tuberculosis [J]. Journal of clinical research, 2014, (12): 2436-2438243-9. DOI: 10.3969 / j.i SSN. 1671-7171.2014.12.052.

[4] Xie Zhi-en, Li Hui-ru, Song Min, Fang Wei-jun, Liu Zeng-Wei, Cao Zhan-zhao. Computed tomography (CT) and magnetic resonance imaging in the diagnosis of spinal tuberculosis in patients with the clinical value of study [J]. Chinese journal of CT and MRI, 2021, 12 (9): 167-169. The DOI: 10.3969 / j.i SSN. 1672-5131.2021.09.053.

[5] Ning, Zhang, Xianjun, Zeng, Laichang, He, Zhili, Liu, Jiaming, Liu, Zhihong, Zhang, Xuanyin, Chen, Yong, Shu. The Value of MR Imaging in Comparative Analysis of Spinal Infection in Adults: Pyogenic Versus Tuberculous [J]. World neurosurgery, 2019128: e806 - e813. DOI: 10.1016 / j. neu. 2019.04.260.

[6] Bony destruction types of spinal tuberculosis in 6, zhang. CT performance analysis [J]. China medical equipment information, 2020, 26(20): 147-149. The DOI: 10.3969 / j.i SSN. 1006-6586.2020.20.075.

[7] Zhang Chao, Zhou Yingfeng, Lu Tan, Zhao Hongxing, Geng Xiaolin, Tao Jingang, Xu Haibin. The value of SPECT/CT and MRI in differentiating spinal tuberculosis from spinal tumors [J]. Chinese journal of CT and MRI, 2022, 20(1): 176-178. The DOI: 10.3969 / j.i SSN. 1672-5131.2022.01.056.

[8] Zhang HC, Ruan QL, wu J, et a1. Serial T-spot. TB in household contacts of tuberculosis patients: A 6-year observational study on China [J]. Int J Tuberc Lung Dis, 2019, 23(9): 989-995.

[9] Zhang R, Tian P, Zhao S, et al. Development and validation of novel diagnostic nomogram for tuberculous pleurisy based on TB-IGRA results [J]. Int J Tuberc Lung Dis, 2020, 24 (11): 1178-1185.

[10] Ming Min, Yang Zengmin, Chen Qiyi. Thoracolumbar spinal tuberculosis with different surgical approach the clinical effect of contrast [J]. China should, 2020 zhongguo kuangye daxue (5): 511-515. The DOI: 10.3969 / j.i SSN. 1008-1070.2020.05.014.

[11] Qin Haibiao, Yang Jian, Chen Lixian, Huang Xianying. Progress in the surgical treatment of the thoracolumbar tuberculosis [J]. Journal of minimally invasive medicine, 2022, (1): 11-15. DOI: 10.11864 / j.i SSN 1673.2022.01.03.

[12] Chen Yaolong, Yang Yinjun, Liu Yongming, Yang Bowen. Research progress in the treatment of spinal tuberculosis [J]. Journal of Orthopaedic Clinic & Research, 202, 7(3):185-188. DOI: 10.19548/ J.2096-269x.2022.03.011.

[13] Jiang Zhi, Qu Manying, Wan Ke. Drug-resistant TB of the spine clinical curative effect analysis and research [J]. Chinese journal of modern medicine, 2016, 26 (11): 132-136. DOI: 10.3969 / j.i SSN. 1005-8982.2016.11.029.

How to cite this paper

Clinical Study of 566 Cases of Senile Spinal Tuberculosis

How to cite this paper: Lilan Wu, Manying Qu, Zhi Jiang, Ke Wan. (2022) Clinical Study of 566 Cases of Senile Spinal Tuberculosis. International Journal of Clinical and Experimental Medicine Research6(4), 413-418.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.10.015