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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 Downloads: 235663 Total View: 2598170
Frequency: quarterly ISSN Print: 2575-7989 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2023.01.002

Relationship between Arterial Calcification and Fetuin-A Levels in Patients with Chronic Kidney Disease at the Onset of Hemodialysis

Felipe José de Moura Vianna1, André Falcão Pedrosa Costa2,*, Luciene Machado dos Reis3, Marcello Fabiano de Franco4, Fausto Miranda Junior5

1Masters in Science from Escola Paulista de Medicina, Vascular Surgeon at the Alagoas State General Hospital, Brazil.

2Professor at Federal University of Alagoas, Brazil.

3Research Biologist at LIM 16 University of São Paulo, Brazil.

4Professor-Retired- Affiliate professor in the Department of Pathology of Federal University of Sao Paulo, Brazil.

5Professor at Federal University of São Paulo, Brazil.

*Corresponding author: André Falcão Pedrosa Costa

Published: January 29,2023

Abstract

Introduction: Arterial calcification is a negative predictor of morbidity and mortality in end-stage renal disease.  Traditional factors such as hypertension, dyslipidemia and non-traditional factors such as mineral disorders are involved in calcification.  They are generally classified as promoters and inhibitors.  Possible changes in inhibiting factors, such as fetuin-A, are responsible for the pathophysiology of vascular calcification.  Method: Arterial calcification was evaluated by withdrawing fragments of the artery to undergo the first arteriovenous fistula for hemodialysis.  Four histological stains were used to identify the presence of calcification while blood for fetuin determination was collected at the same time.  Demographic, clinical and laboratory data were analyzed to test possible relationships in the prevalence of vascular calcification.  Results: Thirty-four patients were enrolled and vascular calcification was detected in eight.  Statistical analysis revealed that calcification predictors were age and the presence of diabetes.  The correlation between arterial calcification and fetuin was 0.4 (r = of 0.033).  Conclusion: There is a tendency to an inverse correlation between arterial calcification and fetuin-A levels in patients with chronic kidney disease at the onset of hemodialysis.

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How to cite this paper

Relationship between Arterial Calcification and Fetuin-A Levels in Patients with Chronic Kidney Disease at the Onset of Hemodialysis

How to cite this paper: Felipe José de Moura Vianna, André Falcão Pedrosa Costa, Luciene Machado dos Reis, Marcello Fabiano de Franco, Fausto Miranda Junior. (2023) Relationship between Arterial Calcification and Fetuin-A Levels in Patients with Chronic Kidney Disease at the Onset of Hemodialysis. International Journal of Clinical and Experimental Medicine Research7(1), 11-16.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.01.002