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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 201038 Total View: 2386908
Frequency: quarterly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2023.01.013

T-lymphocyte Subsets Assessment of the Efficacy of PD-L1 Inhibitors in Combination with Chemotherapy in the First-line Treatment of Elderly with Extensive-stage Small Cell Lung Cancer

Zhaoxue Lu1,3,*, Ying Li2,3, Xuguang Zhang2,3

1Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

2Department of Radiation Oncology, Xuzhou Cancer Hospital, Xuzhou, Jiangsu, China.

3First Clinical College, Xuzhou Medicine University, Xuzhou, Jiangsu, China.

*Corresponding author: Zhaoxue Lu

Published: February 6,2023

Abstract

Objective: To investigate the clinical efficacy of PD-L1 inhibitor combined with chemotherapy in the treatment of elderly extensive-stage small cell lung cancer and the changes of T lymphocyte subsets before and after treatment. Methods: Sixty-four elderly patients admitted to the Affiliated Hospital of Xuzhou Medical University from September 2020 to May 2022 who met the inclusion criteria for primary diagnosis of extensive-stage small cell lung cancer were selected, 34 patients in the control group and 30 patients in the observation group. All patients in the control group were given platinum-based etoposide regimen chemotherapy, while patients in the observation group were treated with dulvalizumab or atelelizumab combined with platinum-etoposide. The tumor markers, lymphocyte subsets, progression-free survival and depth of remission were compared between the two groups after 4 courses of treatment. Results: The CD3+, CD4+ and CD4+/CD8+ T lymphocyte ratios in the observation group were significantly higher than those in the control group, with statistically significant differences (P< 0.05) while there was no significant difference between the two CD8+ groups after treatment, (P> 0.05). Progression-free survival (7.5 months vs. 5.9 months, P = 0. 013), the depth of remission in the observation group was better than that in the control group. Conclusion: PD-L1 inhibitor combined with chemotherapy for distant metastatic small cell lung cancer effectively modulates T-lymphocyte subpopulation, improves the body's immune capacity, and achieves better survival benefit.

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How to cite this paper

T-lymphocyte Subsets Assessment of the Efficacy of PD-L1 Inhibitors in Combination with Chemotherapy in the First-line Treatment of Elderly with Extensive-stage Small Cell Lung Cancer

How to cite this paper: Zhaoxue Lu, Ying Li, Xuguang Zhang. (2023) T-lymphocyte Subsets Assessment of the Efficacy of PD-L1 Inhibitors in Combination with Chemotherapy in the First-line Treatment of Elderly with Extensive-stage Small Cell Lung Cancer. International Journal of Clinical and Experimental Medicine Research7(1), 73-77.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.01.013