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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 Downloads: 238099 Total View: 2613984
Frequency: quarterly ISSN Print: 2575-7989 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2023.07.021

Mechanisms by Which Spinal Cord Stimulation Intervenes in Atrial Fibrillation: The Involvement of the Endothelin-1 and Nerve Growth Factor/P75ntr Pathways

Yiyan Peng1, Peng Li2,3,4,*, Wei Hu2,3,4, Qi Shao1, Panpan Li2,4, Haiyue Wen2,4

1Postgraduate Training Base of Jinzhou Medical University (Xiaogan Central Hospital), Xiaogan, Hubei, China.

2Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China.

3Xiaogan Central Hospital, Xiaogan, Hubei, China.

4Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, Hubei, China.

*Corresponding author: Peng Li

Published: August 15,2023

Abstract

Background: The cardiac autonomic nervous system (CANS) plays an integral role in normal cardiac physiology and the pathogenesis that leads to arrhythmias. CANS consists of complex neural hierarchies in a series of interacting feedback loops that regulate atrial electrophysiology and are inherently susceptible to remodeling of atrial rhythms. In addition to the use of tradition-al medicines and ablation techniques to treat atrial fibrillation, there is also increasing interest in the use of spinal cord stimulation as an invasive method to modulate the autonomic axis of the heart. Objective: Can the spinal cord stimulation regulate the autonomic nerves through the ET-1 and NGF/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation? Methods: Sixteen beagles were randomly divided into a RAP group (n=8) and a RAP+SCS group (n=8), and the effective refractory period (ERP), ERP dispersion, atrial fibrillation induction rate, and atrial fibrillation vulnerability window (WOV) at baseline, 6 hours of RAP, 6 hours of RAP+SCS were measured. The atrial tissue was then taken for immunohistochemical analysis to dertermine the localization of endothelin-1 (ET-1), nerve growth factor (NGF), p75NTR, NF-kB p65 and other genes. Results: Our results showed that SCS attenuated the shortening of ERP in all parts caused by RAP, and after 6 hours of SCS, the probability of atrial fibrillation in dogs was reduced compared with that in the RAP group. Moreover, the expression of ET-1, NGF and p75NTR in the atrial tissues of dogs in the RAP+SCS group was significantly increased, but the expression of NF-kB p65 was reduced. Conclusion: Spinal cord stimulation promotes the positive remodeling of cardiac autonomic nerves by weakening NFκB p65-dependent pathways to interfere with the ET-1 and NGF/p75NTR pathways to resist the original negative re-modeling and inhibit the occurrence of atrial fibrillation.

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How to cite this paper

Mechanisms by Which Spinal Cord Stimulation Intervenes in Atrial Fibrillation: The Involvement of the Endothelin-1 and Nerve Growth Factor/P75ntr Pathways

How to cite this paper: Yiyan Peng, Peng Li, Wei Hu, Qi Shao, Panpan Li, Haiyue Wen. (2023) Mechanisms by Which Spinal Cord Stimulation Intervenes in Atrial Fibrillation: The Involvement of the Endothelin-1 and Nerve Growth Factor/P75ntr Pathways. International Journal of Clinical and Experimental Medicine Research7(3), 407-415.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.07.021