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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 Downloads: 499635 Total View: 4296536
Frequency: bimonthly ISSN Print: 2575-7989 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2023.07.022

Investigate the Function and Immune Correlation of the Methylation Modification of m6A Regulators in DLBCL

Yuna Meng, Lixian Gao, Baoying Duan, Wenjiao Huang, Fang Wan*

The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, Gansu, China.

*Corresponding author: Fang Wan

Published: August 15,2023

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the major subtype of non-Hodgkin lymphoma, whose treatment still has a major challenge. The dysregulation of N6-methyladenosine (m6A) modification is a common type of messenger ribonucleic acid (mRNA) modification. However, there is a lack of research into m6A RNA methylation regulators in DLBCL. Methods: We down loaded the data of 48 patients from The Cancer Genome Atlas (TCGA) database. The relationship between the expression level of m6A RNA methylation regulators and clinicopathological variables in DLBCL was analyzed by R language. Results: The results showed that the expression of m6A gene was abnormal in DLBCL tissues compared with normal tissues (P<0.05). GO functional analysis showed that m6A gene was involved in different biological functions during the development of DLBCL. The alteration of m6A gene is correlated with tumor stage and immune function. Next, according to ssGSEA algorithm, IGF2BP2 and YTHDF2 are correlated with a number of signaling pathways, which can provide a theoretical basis for further research on the occurrence and development mechanism of DLBCL. Conclusions: The m6A RNA methylation regulators are involved in DLBCL cancer progression.

Keywords

m6A, DLBCL, IGF2BP2, YTHDF2

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How to cite this paper

Investigate the Function and Immune Correlation of the Methylation Modification of m6A Regulators in DLBCL

How to cite this paper: Yuna Meng, Lixian Gao, Baoying Duan, Wenjiao Huang, Fang Wan. (2023) Investigate the Function and Immune Correlation of the Methylation Modification of m6A Regulators in DLBCL. International Journal of Clinical and Experimental Medicine Research7(3), 416-422.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.07.022