Effects of Atorvastatin on Myocardial Ischemia-Reperfusion Injury and Ventricular Remodeling in Rats

Abstract

Objective: To investigate the protective effects of atorvastatin on multiple organs and ventricular remodeling during myocardial ischemia-reperfusion in rats. Methods: 45 rats were randomly divided into 3 groups with 15 rats in each group, including atorvastatin group, ischemia reperfusion group and sham operation group. After completing the vegetation of myocardial ischemia-reperfusion injury model of rats, 8 rats were selected from atorvastatin group and ischemia-reperfusion group respectively, and were stained with Evans blue and TTS. Then, image analysis software was used to calculate the infarct area. The myocardial tissue of vegetation rats was homogenized, and MDA content was determined by TBA method. The contents of TNF-α and MPO were determined by ELISA. The hemodynamic indexes and key indexes of ventricular remodeling in the remaining rats were detected and analyzed 14 days after surgery. Results: Comparing the atorvastatin group with the reper-fusion group, it was found that the myocardial infarction area in the atorvastatin group was smaller, and the myocardial infarction area without ischemia was larger, and the ratio of myocardial infarction area to the total ischemic area was significantly smaller than that in the reperfusion group (p<0.05). MDA, TNF-α and MPO were significantly increased in the ischemia-reperfusion group and atorvastatin group compared with the sham operation group, but the increase was less in the atorvastatin group. Compared with the ischemia reperfusion group, the hemodynamics and left ventricular function remodeling improved significantly (p<0.05). Conclusion: Atorvastatin can effectively reduce the infarct size after ischemia reperfusion palpitation, improve the hemodynamics and left ventricle, achieve multi-organ protection, conducive to ventricular remodeling, and can be used in clinical application.