International Journal of Clinical and Experimental Medicine Research

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Article http://dx.doi.org/10.26855/ijcemr.2023.10.009

The Expression Level of CD47 in Glioma and its Impact on Invasiveness

Jun Zhou1,*, Eddie Guo2, Senia Ma2, Hok Shing Li3, Kai Jia4

1Wuhan Zhi School Culture and Media Co., Ltd., Wuhan, Hubei, China.

2Beijing Qingmiao International Bilingual School, Beijing, China.

3Pennsylvania State University, Pennsylvania, PA, USA.

4Schveya (Tianjin) Pharmaceutical Co., Ltd., Tianjin, China.

*Corresponding author: Jun Zhou

Published: November 30,2023

Abstract

Objective: To investigate the expression level of CD47 in glioma and assess its influence on the invasiveness of tumor cells. Methods: A total of 30 glioma brain tissue specimens and 10 normal brain tissue control specimens were selected. Real-time fluorescence quantitative PCR (RT-PCR), Western Blot analysis and invasion assay were used to analyze the effects of low and high expression levels of CD47 on the aggressiveness of glioma cells. Results: The expression of CD47 in glioma cells was found to be significantly high. Conversely, a notable decrease in CD47 expression resulted in a significant inhibition of tumor cell aggressiveness. On the other hand, an increased expression of CD47 was observed to significantly promote tumor cell aggressiveness (P<0.05). Conclusion: CD47 is highly expressed in glioma cells, and a decrease in CD47 expression of CD47 significantly inhibits the aggressiveness of tumor cells. CD47 serves as a significant prognostic factor and potential therapeutic target in glioma.

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How to cite this paper

The Expression Level of CD47 in Glioma and its Impact on Invasiveness

How to cite this paper: Jun Zhou, Eddie Guo, Senia Ma, Hok Shing Li, Kai Jia. (2023) The Expression Level of CD47 in Glioma and its Impact on Invasiveness. International Journal of Clinical and Experimental Medicine Research7(4), 573-578.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.10.009