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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 225455 Total View: 2530029
Frequency: quarterly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2020.10.004

Evaluation of Some Coagulation Profile and Estimation of Fibrinogen Level in Sudanese Patients with Type II Diabetes Mellitus

Amged Husssien Abdelrhman *, Abdegadir Ahmed Abdelgadir

Department of Hematology and Immunohematology, Omdurman Islamic University, Sudan.

*Corresponding author: Amged Husssien Abdelrhman

Published: August 20,2020

Abstract

Background: Type II diabetes, fibrinogen levels have been demonstrated to predict the progression to overt nephropathy. Hyperfibrinogenemia, an indi-cator of inflammation, is also associated with the presence of endothelial dys-function, insulin resistance, hypercoagulability, and increased blood viscosity and is a marker of unstable atherosclerotic lesions. Aim: This study aimed to evaluation of coagulation profile and D. Dimer and estimation of Serum Fi-brinogen Level in Sudanese Patients with type II Diabetes Mellitus in Khartoum State. Methods: A questionnaire was designed to collect information about the study group, Blood sample were collected from all participants in Tri sodium citrate containers. Automated coagulometer (COATRON M1) was used to evaluate prothrombine time and activated partial thromboplastine time and measure fibrinogen level. D-dimer levels were evaluated using (ichroma™) Reader fluorescence scanning instrument an integrated Point of Care Test (P.O.C.T.) system. Results: The study showed that the mean and Std of PT, APTT, INR was (17.9 ± 3.8 sec, 32.6 ± 4.1 sec, 1.1 ± 0.3 respectively), the mean of age among study group was (53 ± 14.2 years), there was significant different when correlate PT and management of disease (p. value 0.01). Conclusion: The present study show that shortened prothrombin time, acti-vated partial thromboplastin time, shortened PT and APTT might be useful hemostatic markers in diabetic patients, especially in those at high risk for thrombotic complications.

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How to cite this paper

Evaluation of Some Coagulation Profile and Estimation of Fibrinogen Level in Sudanese Patients with Type II Diabetes Mellitus

How to cite this paper: Amged Husssien Abdelrhman, Abdegadir Ahmed Abdelgadir. (2020) Evaluation of Some Coagulation Profile and Estimation of Fibrinogen Level in Sudanese Patients with Type II Diabetes Mellitus. International Journal of Clinical and Experimental Medicine Research, 4(4), 138-144.

DOI: http://dx.doi.org/10.26855/ijcemr.2020.10.004