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Phytochemicals and Their Antimicrobial Activity: An Update on Their Mode of Action

Date: January 19,2021 |Hits: 5890 Download PDF How to cite this paper

Sravanthi Pammi S. S.1,*, Archana Giri2

1Department of Botany, SVRK (M) GDC, Nidadavole, W.G.DT., A.P, India.

2Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500 085, India.

*Corresponding author: Sravanthi Pammi S. S.


Introduction: Plants have been considered as potential alternative for antimicrobial antibiotics owing to vast reserve of secondary metabolites. Last few decades have experienced an upsurge in demand and delivery of herbal products for health benefits as plant derived bioactive compounds have capability to interact with a wide variety of targets. The main focus of this review was to congregate vital information related to imperative bioactive components of medicinal plants having therapeutic potential with particular reference to antimicrobial activity against pathogenic bacteria. Our study intended to comprehend the mode of action of these phytopharmaceuticals for their scientific validation and drug development. Methods: A narrative review of papers reporting antimicrobial activity of medicinal plants against pathogenic bacteria, identification of the prospective bioactive compounds with antimicrobial potential and understanding their mechanism of action has been envisaged.  Results: This review includes anthology of recent published information on phytoconstituents of various medicinal plants belonging to different families around the globe, tested and validated against various pathogenic bacteria. This study unveils the treasure of antimicrobial potential of plant species, which is also an appraisal of information related to mechanism of action of these phytochemicals required for their antimicrobial activity. Conclusions: There is resurgence in use of herbal medicines and identification of pharmacologically active compounds with their scientific validation. It will play a pivotal role in perpetuating and promoting wider usages of drugs based on plant extracts. A missing link for establishment of phytocompounds as an alternative drug requires understanding their mode of action and exploitation.


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How to cite this paper

Phytochemicals and Their Antimicrobial Activity: An Update on Their Mode of Action

How to cite this paper: Sravanthi Pammi S. S., Archana Giri. (2021) Phytochemicals and Their Antimicrobial Activity: An Update on Their Mode of Action. International Journal of Clinical and Experimental Medicine Research5(1), 41-69.

DOI: http://dx.doi.org/10.26855/ijcemr.2021.01.008

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