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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 226095 Total View: 2534904
Frequency: quarterly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2021.04.001

Review on Therapeutic Efficacy of Mesenchymal Stem Cell (MSC) Therapy for Treating Different Disease

Farhana Hoque, Saima Akther, Md. Shahidul Islam*

Department of Pharmacy, University of Science and Technology Chittagong (USTC), Chattogram, Bangladesh.

*Corresponding author: Md. Shahidul Islam

Published: February 23,2021

Abstract

Mesenchymal stem cells (MSCs) have been demonstrated as an attractive cell source for tissue engineering applications because of their ability to be easily isolated and expanded from adult bone marrow, umbilical cord, adipose tissue etc and their versatility for differentiation into multiple cells and tissues. The research is conducted by studying 80 different articles and journals focusing on the efficacy and success of MSC therapy for different disease like Vertebral Disc Regeneration, Craniofacial defects repairmen, Skeletal Muscle Re-pairmen, Cardiovascular disease, Osteoarthritis, Renal Disease, Type 1 Di-abetes, Multiple sclerosis, liver disease, Tendon & Ligament repair, Bone fracture and also for treating COVID patients. Reports of multiple clinical trials conducted upon more than 1,000 patients for treating diversified diseases has been included in this review to study the effectiveness and limitations of MSC Therapy. The results and discussion concluded with appreciative therapeutic outcome of most of the clinical trials conducted and there were few cases in which MSC Therapy failed to generate therapeutic response. Three major limitations and governing factor were found out to the reasons behind the success and failure of the therapy. This special issue has provided unprecedented insights into the roles of human MSC in treating numerous diseases and highlighted the remaining challenges and possible strategies to enhance their therapeutic potential. Despite significant advancements in MSC therapy understanding of the nature, function, mechanism, mode of isolation, and route of administration as well as experimental handling of MSCs is important to improve the therapeutic efficacy of MSCs. The therapeutic potential of MSCs will attract further research investments in this area to resolve the challenges and improve the effectiveness of medical treatment. Thus, it can be concluded that MSC Therapy can open a vast field of exploring regenerative drug.

References

[1] Pountos, I., Corscadden, D., Emery, P., Giannoudis, P. V. (2007). Mesenchymal stem cell tissue engineering: techniques for isolation, expansion and application. Injury. 2007 Sep 1; 38: S23-33.

[2] Arthur, A., Zannettino, A., Gronthos, S. (2009). The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. Journal of Cellular Physiology. 2009 Feb; 218(2): 237-45.

[3] Song, L., Baksh, D., Tuan, R. S. (2004). Mesenchymal stem cell-based cartilage tissue engineering: cells, scaffold and biology. Cyto therapy. 2004 Dec 1; 6(6): 596-601.

[4] Vacanti, J. P., Langer, R. (1999). Tissue engineering: the design and fabrication of living replacement devices for surgical re-construction and transplantation. The lancet. 1999 Jul 1; 354: S32-4

[5] Audet, J. (2004). Stem cell bioengineering for regenerative medicine. Expert Opinion on Biological Therapy. 2004 May 1; 4(5): 631-44.

[6] Concise review: mesenchymal stem cell therapy for pediatric disease: perspectives on success and potential improvements. Stem Cells Translational Medicine. 2017 Feb; 6(2): 539-65.

[7] Lee, K. Y., Mooney, D. J. (2001). Hydrogels for tissue engineering. Chemical Reviews. 2001 Jul 11; 101(7): 1869-80.

[8] Steinert, A. F., Ghivizzani, S. C., Rethwilm, A., Tuan, R. S., Evans, C. H., Nöth, U. (2007). Major biological obstacles for per-sistent cell-based regeneration of articular cartilage. Arthritis Research & Therapy. 2007 Jun 1; 9(3): 213.

[9] Jana, S., Levengood, S. K., Zhang, M. (2016). Anisotropic materials for skeletal‐muscle‐tissue engineering. Advanced Materials. 2016 Dec; 28(48): 10588-612.

[10] Mauney, J. R., Volloch, V., Kaplan, D. L. (2005). Role of adult mesenchymal stem cells in bone tissue engineering applications: current status and future prospects. Tissue Engineering. 2005 May 1; 11(5-6): 787-802.

[11] Saeedi, P., Halabian, R., Fooladi, A. A. (2019). A revealing review of mesenchymal stem cells therapy, clinical perspectives and modification strategies. Stem Cell Investigation. 2019; 6.

[12] McInnes, I. B., Schett, G. (2011). The pathogenesis of rheumatoid arthritis. New England Journal of Medicine. 2011 Dec 8; 365(23): 2205-19.

[13] Tsuchiya, A., Takeuchi, S., Iwasawa, T., Kumagai, M., Sato, T., Motegi, S., Ishii, Y., Koseki, Y., Tomiyoshi, K., Natsui, K., Takeda, N. (2020). Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases. Inflammation and Regeneration. 2020 Dec; 40(1): 1-6.

[14] Loy, H., Kuok, D. I., Hui, K. P., Choi, M. H., Yuen, W., Nicholls, J. M., Peiris, J. M., Chan, M. C. (2019). Therapeutic Impli-cations of Human Umbilical Cord Mesenchymal Stromal Cells in Attenuating Influenza A (H5N1) Virus–Associated Acute Lung Injury. The Journal of Infectious Diseases. 2019 Jan 7; 219(2): 186-96.

[15] Chen, J., Hu, C., Chen, L., Tang, L., Zhu, Y., Xu, X., Chen, L., Gao, H., Lu, X., Yu, L., Dai, X. (2020). Clinical study of me-senchymal stem cell treating acute respiratory distress syndrome induced by epidemic Influenza A (H7N9) infection, a hint for COVID-19 treatment. Engineering. 2020 Feb 28.

[16] Leng, Z., Zhu, R., Hou, W., Feng, Y., Yang, Y., Han, Q., Shan, G., Meng, F., Du, D., Wang, S., Fan, J. (2020). Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia. Aging and Disease. 2020 Apr; 11(2): 216.

[17] Wei, A., Shen, B., Williams, L., Diwan, A. (2014). Mesenchymal stem cells: potential application in intervertebral disc rege-neration. Translational Pediatrics. 2014 Apr; 3(2): 71.

[18] Lukomska, B., Stanaszek, L., Zuba-Surma, E., Legosz, P., Sarzynska, S., Drela, K. (2019). Challenges and controversies in human mesenchymal stem cell therapy. Stem Cells International. 2019 Apr 9.

How to cite this paper

Review on Therapeutic Efficacy of Mesenchymal Stem Cell (MSC) Therapy for Treating Different Disease

How to cite this paper: Farhana Hoque, Saima Akther, Md. Shahidul Islam. (2021) Review on Therapeutic Efficacy of Mesenchymal Stem Cell (MSC) Therapy for Treating Different Disease. International Journal of Clinical and Experimental Medicine Research5(2), 96-100.

DOI: http://dx.doi.org/10.26855/ijcemr.2021.04.001