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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 521920 Total View: 4481775
Frequency: bimonthly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2026.01.001

Study on the Levels of Gingival Crevicular Fluid Cytokines and Periodontal Status in Patients with Anterior Teeth Fan-shaped Displacement Treated with Orthodontic-periodontal Splint Therapy

Xin Xia*, Haixia Ren, Xiaobo Cheng

Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.

*Corresponding author: Xin Xia

Published: January 9,2026

Abstract

Objective: This study focuses on the combined application of orthodontic treatment and periodontal splinting, aiming to deeply explore the specific effects of this therapy on the levels of gingival crevicular fluid cytokines and periodontal health status in patients with anterior tooth fan-shaped displacement. Methods: A total of 62 patients with anterior tooth fan-shaped displacement who received combined orthodontic and periodontal splinting treatment between January 2022 and December 2023 were included in the study. They were divided into two groups based on different treatments. The control group (31 cases) received periodontal splinting treatment, while the observation group (31 cases) received combined orthodontic and periodontal splinting treatment. The levels of gingival crevicular fluid cytokines [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6)] and plaque index (PLI) scores were compared between the two groups. Results: After treatment, the IL-6 and TNF-α levels in the observation group were lower than those in the control group, and the PLI score was also lower than that in the control group (P < 0.05). Conclusion: Combined orthodontic and periodontal splinting treatment for patients with anterior tooth fan-shaped displacement can reduce the levels of gingival crevicular fluid cytokines and improve periodontal status.

Keywords

Orthodontics; periodontal splint; anterior tooth fan-shaped displacement; gingival crevicular fluid cytokines; periodontal status

References

[1] Qian, Y., Deng, C., Xu, X. B., et al. Evaluation of the effect of 3D printing resin splint based on the retention effect of orthodontic treatment in patients with periodontal disease. Shanghai Kou Qiang Yi Xue. 2023;32(3):323-7.

[2] Bumbar, Z. O., Sichkoriz, K. A., Bumbar, O. I., et al. The orthodontic treatment and the periodontal status of patients. Wiad Lek. 2024;77(3):602-7.

[3] Kučera, J., Marek, I., & Littlewood, S. J. The effect of different bonded retainer wires on tooth mobility immediately after orthodontic treatment. Eur J Orthod. 2022;44(2):178-86.

[4] Huang, H. X. Periodontology[M]. Beijing: People's Health Publishing House; 2013: 123-124.

[5] Wang, H. Y., Zhang, W. B., Lai, D. F., et al. Analysis of Efficacy and Long-term Effectiveness Factors of Orthodontic Combined with Periodontal Splint Treatment for Anterior Tooth Fan-shaped Displacement Caused by Periodontitis. J Clin Exp Med. 2024;23(5):543-7.

[6] Zhu, G. H., Li, X. J., & Ying, X. M. Effects of Orthodontic Combined with High-strength Fiber Periodontal Splint on Periodontal Health, Osteocalcin, and Facial Aesthetics in Patients with Anterior Tooth Fan-shaped Displacement Due to Periodontitis. Chin J Aesthetic Med. 2025;34(1):173-6.

[7] Zhu, A. M. Clinical Effect and Impact on Inflammatory Factors of Orthodontic Combined with Periodontal Splint Treatment for Anterior Tooth Fan-shaped Displacement Caused by Periodontitis. Chin Foreign Med Treat. 2023;42(18):48-52.

[8] Ye, X. W., Chen, J. W., & Zhou, X. Q. Clinical Efficacy Observation of Orthodontic Combined with Periodontal Splint Treatment for Anterior Tooth Fan-shaped Displacement Caused by Periodontitis. Chin Med Device Inf. 2024;30(11):151-3.

[9] Wang, B., Ji, T., Fang, M., et al. Effects of Orthodontic Combined with Periodontal Splint Treatment on Gingival Crevicular Fluid RANKL, OPG, Elastase, and Its Inhibitory Factor in Patients with Anterior Tooth Displacement Due to Periodontal Disease. J Lab Med Clin. 2024;21(23):3494-8.

[10] Xu, Y. Effects of Orthodontic Combined with Periodontal Splint versus Simple Periodontal Splint Treatment on Dental Function and Aesthetic Outcomes in Patients with Anterior Tooth Displacement Due to Periodontal Disease. Chin J Aesthetic Med. 2022;31(11):150-3.

How to cite this paper

Study on the Levels of Gingival Crevicular Fluid Cytokines and Periodontal Status in Patients with Anterior Teeth Fan-shaped Displacement Treated with Orthodontic-periodontal Splint Therapy

How to cite this paper: Xin Xia, Haixia Ren, Xiaobo Cheng. (2026) Study on the Levels of Gingival Crevicular Fluid Cytokines and Periodontal Status in Patients with Anterior Teeth Fan-shaped Displacement Treated with Orthodontic-periodontal Splint Therapy. International Journal of Clinical and Experimental Medicine Research, 10(1), 1-4.

DOI: http://dx.doi.org/10.26855/ijcemr.2026.01.001