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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 194470 Total View: 2354313
Frequency: quarterly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2022.01.013

A Gait Analysis Study on Charcot-Marie-Tooth Patients

A. Mehrpouya1, M. Haddadi Dashtbayaz1, A. Zarif Allali1, A. Ashofteh Yazdi1,*, R. Boostani2

1Department of Biomechanics, Faculty of Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Razavi Khorasan province, Iran.

2Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan province, Iran.

*Corresponding author: A. Ashofteh Yazdi

Published: January 18,2022

Abstract

The aim of this study was to quantitatively investigate the kinematics and kinetics characteristics of Charcot-Marie-Tooth patients, in order to extract motion model parameters and provide objective diagnostic criteria. Charcot-Marie-Tooth (CMT) is the most common disease among all neuropathies of the peripheral nervous system and leading to disturbances in walking and balance in the person. For this purpose, the motion analysis approach was performed on a group of patients with CMT (N =5) and a control (healthy) group (N =5). By recording the spatial and temporal parameters of participant’s joints with QTM software, the appropriate non-linear models of motion were extracted. To the purpose of providing CMT diagnostic criteria, the coefficients of kinematic and kinematic model parameters were compared for the two sample groups. The results showed the highest decrease in the range of motion and angular velocity of the knee and ankle joints from healthy to patient samples, while no significant changes were observed for the hip joint. The changes in motion model parameters were mostly observed in directions y and x, while the maximum peripheral kinetic parameters were measured in the fore-heel for the patients compared to the healthy group.

References

[1] Krajewski, K. M., et al. (2000). Neurological dysfunction and axonal degeneration in Charcot–Marie–Tooth disease type 1A. Brain, 123(Pt 7): 1516-27. 

[2] Szigeti, K., Lupski, J. R. (2009). Charcot–Marie–Tooth disease. European Journal of Human Genetics, 17: 703-710.

[3] Jani-Acsadi, A., et al. (2008). Charcot-Marie-Tooth Neuropathies: Diagnosis and Management. Neuromuscular Disorders; M.D.Semin Neurol, 28: 185-194. 

[4] Yiu Eppie, M., et al. (2008). Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A. Journal of the Peripheral Nervous System, 13(3): 236-41. 

[5] Gemignani, F., et al. (1999). Charcot–Marie–Tooth disease type 2 with restless legs syndrome. Neurology, 52: 1064-1066.

[6] Mostacciuolo, M. L., et al. (2001). Charcot–Marie–Tooth disease type I and related demyelinating neuropathies: mutation analysis in a large cohort of Italian families. Human Mutation, 18: 32-41.

[7] Berciano, J., et al. (2011). Charcot-Marie-Tooth disease: a review with emphasis on the pathophysiology of pes cavus. Revista Española de Cirugía Ortopédica y Traumatología (English Edition), 55(2): 140-150.

[8] Le, T., Bhushan, V. (2001). 201 First Aid for the USMLE Step 14. McGraw-Hill Education, USA.

[9] Soykan, I., McCallum, R. W. (1997). Gastrointestinal involvement in neurologic disorders: Stiff-man and Charcot–Marie–Tooth syndromes. The American Journal of the Medical Sciences, 313(1): 70-73. 

[10] Fernando, M., et al. (2013). Biomechanical characteristics of peripheral diabetic neuropathy: A systematic review and meta-analysis of findings from the gait cycle, muscle activity and dynamic barefoot plantar pressure. Clinical Biomechanics, 28: 831-845.

[11] Huang, C. K., et al. (2019). An altered spatiotemporal gait adjustment during a virtual obstacle crossing task in patients with diabetic peripheral neuropathy. Journal of Diabetes and its Complications, 33: 182-188.

[12] Fernando, M., et al. (2013). Biomechanical characteristics of peripheral diabetic neuropathy: A systematic review and meta-analysis of findings from the gait cycle, muscle activity and dynamic barefoot plantar pressure. Clinical Biomechanics, 28: 831-845.

[13] Leardini, A., et al. (2007). Rear-foot, mid-foot and forefoot motion during the stance phase of gait. Gait Posture, 25: 453-462.

[14] Manal, K., Stanhope, S. J. (2004). A novel method for displaying gait and clinical movement analysis data. Gait Posture, 20: 222-226.

[15] De Ridder, R., et al. (2013). Gait kinematics of subjects with ankle instability using a multisegmented foot model. Medicine & Science in Sports & Exercise, 45: 2129-36.

[16] Fernando, M., et al. (2013). Biomechanical characteristics of peripheral diabetic neuropathy: A systematic review and meta-analysis of findings from the gait cycle, muscle activity and dynamic barefoot plantar pressure. Clinical Biomechanics, 28: 831-845.

[17] Rezende, A., et al. (2013). Muscle strength and ankle mobility for the gait parameters in diabetic neuropathies. Clinical Bio-mechanics, 23: 17-21.

[18] Deschamps, K., et al. (2013). Comparison of foot segmental mobility and coupling during gait between patients with diabetes mellitus with and without neuropathy and adults without diabetes. Clinical Biomechanics, 28: 813-819.

[19] Ashofteh Yazdi, A., Esteki, A., and Dehghan, M. M. (2019). Determination of an average quasi-linear viscoelastic model for the mechanical behavior of rat cervix. Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, 233(5): 924-929.

[20] Yazdi, A. A., Esteki, A., Dehghan, M. M., and Ghomsheh, F. T. (2016). Characterization of viscoelastic behavior of rat cervix in the last trimester of pregnancy. Biomed Res, 27(4): 1194-1200.

[21] Yazdi, A. A., Melchor, J., Torres, J., Faris, I., Callejas, A., Gonzalez-Andrades, M., and Rus, G. (2020). Characterization of non-linear mechanical behavior of the cornea. Scientific Reports, 10(1): 1-10.

How to cite this paper

A Gait Analysis Study on Charcot-Marie-Tooth Patients

How to cite this paper: A. Mehrpouya, M. Haddadi Dashtbayaz, A. Zarif Allali, A. Ashofteh Yazdi, R. Boostani. (2022) A Gait Analysis Study on Charcot-Marie-Tooth Patients. International Journal of Clinical and Experimental Medicine Research6(1), 74-80.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.01.013