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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 Downloads: 302880 Total View: 2929010
Frequency: quarterly ISSN Print: 2575-7989 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2022.04.002

Characterization of Male OF1cenp Mice with Age-Induced Cognitive Decline

Nashelly Esquivel1,*, Yenela García1, Osmany Carvajal2, Claudio Rodríguez1

1Laboratory of Antianemics and Nutraceutical, National Center of Bioproducts (BioCen), Beltrán main road km 1 1/2, Havana, Mayabeque, Cuba.

2Active Ingredients Plant, National Center of Bioproducts (BioCen), Beltrán main road km 1 1/2, Havana, Mayabeque, Cuba.

*Corresponding author: Nashelly Esquivel

Published: February 14,2022

Abstract

Age is the greatest risk factor for memory loss and other disorders. The aim of this paper was to investigate whether the OF1cenp mouse was suitable for use as a model of age-induced cognitive decline. To achieve this, it was compared male OF1cenp middle aged and aged with young mice for learning abilities and biochemical markers. It was obtained that based on the different mechanisms of memory that was evaluated in the Y-maze test, in the Morris Water Maze and in the Novel Object Task, it can be affirmed that aged male OF1cenp mice from 7-8 months show true cognitive deficits based in the reduction of learning and memory. It was found an increase in glucose, triglycerides and cholesterol concentration in the aged mice. At the age of 7-8 and 15-16 months, a significant decrease in the size of the brain was obtained, on the contrary the liver weight does not show differences. An increase in oxidative damage and a decrease in the antioxidant total capacity in the brains of aged animals was also found in relation to young animals. The correlation of results obtained in relation to behavioral task, hematological and biochemical analyses indicate that OF1cenp mice with 15-16 months of age are a useful model cognitive decline. It can be used to characterize this disorder during aging and evaluate nutritional supplements for its prevention.

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How to cite this paper

Characterization of Male OF1cenp Mice with Age-Induced Cognitive Decline

How to cite this paper: Nashelly Esquivel, Yenela García, Osmany Carvajal, Claudio Rodríguez. (2022) Characterization of Male OF1cenp Mice with Age-Induced Cognitive DeclineInternational Journal of Clinical and Experimental Medicine Research6(2), 111-121.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.04.002