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DOI:http://dx.doi.org/10.26855/ijcemr.2022.07.002

Formulation and Evaluation of Orodispersible Tablets of Etoricoxib Using Hibiscus Rosa Sinesis Muscillage as Natural Super Disintegrant

Date: May 13,2022 |Hits: 716 Download PDF How to cite this paper

Sandeep Patel, Komal Tikariya*, Jayanti Mukherjee

Department of Pharmaceutics, Shri Bherulal Pharmacy Institute, Indore (M.P), India.

*Corresponding author: Komal Tikariya

Abstract

The aim of the study is to formulate orodispersible tablet of Etoricoxib for the pain management of rheumatoid arthritis and to improve the efficacy and patient compliance. In the present work, orodispersible tablets of Etoricoxib were prepared by direct compression method using Hibiscus rosasinesis leaves mucilage as natural super disintegrant with a view to enhance patient compliance and to avoid hepatic first pass metabolism and to improve its bioavailability. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water-absorption ratio and in-vitro dispersion time. Addition of Drug: β-cyclodextrin inclusion complex leads to improve the dissolution characteristics and solubility of drug at optimum concentration (1:5). It was found that the formulation F5 was found to be optimized formulation from the data obtained. It is observed from the formulation F5 which shown disintegration time 30±1.25 sec. and percentage cumulative drug release shown 95.84±2.08 within 30 minute. The best formulations F5 was analyzed for short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro dispersion time. The formulation was found to be stable.

References

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How to cite this paper

Formulation and Evaluation of Orodispersible Tablets of Etoricoxib Using Hibiscus Rosa Sinesis Muscillage as Natural Super Disintegrant

How to cite this paper: Sandeep Patel, Komal Tikariya, Jayanti Mukherjee. (2022) Formulation and Evaluation of Orodispersible Tablets of Etoricoxib Using Hibiscus Rosa Sinesis Muscillage as Natural Super Disintegrant. International Journal of Clinical and Experimental Medicine Research6(3), 222-231.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.07.002

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