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DOI:http://dx.doi.org/10.26855/ijcemr.2022.07.003

Early Onset Sepsis in South Indian Newborns

Date: May 25,2022 |Hits: 163 Download PDF How to cite this paper

Grace Lalana Christopher

Grace Specialist Clinic, #6, 1st Floor, Maruthi Complex, Ramamurthynagar Main Road, Bangalore 560016, South India, India.

*Corresponding author: Grace Lalana Christopher

Abstract

Background: Early onset neonatal sepsis is one of the leading causes of perinatal and neonatal mortality more so in low and moderate income Asian countries. Objective: The objective of the study was to identify various ante-partum, intra-partum and neonatal risk factors associated with Early Onset Sepsis (EOS) in South Indian newborns. Method: The study comprised of 2,750 consecutive singleton live births with 244 “EOS cases” and 2,506 “Controls”. Sources of data were Labor room records, NICU register and neonatal charts. Analysis by binary logistic regression with statistical significance set at 0.05 using SPSS Version 21. Results: The incidence of early onset sepsis in South Indian newborns was 8.9%, high risk factors for EOS include young mothers ≤24 years, OR 1.53, (95% CI 1.2-2.0), P>|z|=0.002, primigravidae, OR 2.08, (95% CI 1.6-2.7) P>|z| <0.001, Premature Rupture of Membranes (PROM), OR 12.96, (95% CI 9.5-18.4), P>|z| <0.001, Gestational diabetes, OR 2.19, (95% CI 1-1.3), P>|z| <0.008, so also birth by emergency Lower Segment Cesarean Section (LSCS), OR 1.82, (95% CI 1.3-2.5), P>|z| <0.001. Neonatal risk factors include prematurity ≤36 weeks, OR 2.57, (95% CI 1.8-3.6), P>|z| <0.001, Low Birth Weight (LBW) ≤2,499g, OR 2.76, (95% CI 2.1-3.7), P>|z| <0.001 and male gender, OR 1.88, (95% CI 1.1-3.0), P>|z| <0.008 being highly statistically significant. Conclusion: The incidence of early onset neonatal sepsis was 8.9%. High index of clinical suspicion for early diagnosis should be based on history of maternal, obstetric and neonatal high risk factors predisposing to EOS.

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How to cite this paper

Early Onset Sepsis in South Indian Newborns

How to cite this paper: Grace Lalana Christopher. (2022) Early Onset Sepsis in South Indian NewbornsInternational Journal of Clinical and Experimental Medicine Research6(3), 232-251.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.07.003

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