Hill Publishing Group | contact@hillpublisher.com

Hill Publishing Group

Location:Home / Journals / International Journal of Clinical and Experimental Medicine Research /


Application of E-D-D-L Four-Dimensional Positioning Precise Injection Technique in Facial Rejuvenation

Date: June 14,2022 |Hits: 181 Download PDF How to cite this paper

Yi Cao

Department of Cosmetic Dermatology, Shanghai Huamei Medical Plastic Surgery Hospital, Shanghai, China.

*Corresponding author: Yi Cao


Objective: To evaluate the clinical efficacy of E-D-D-L four-dimensional precision injection technique in facial rejuvenation. Methods: Eighty-four patients with aging face were selected as study subjects in our hospital from November 2020 to November 2021. All patients were treated with E-D-D-L four- dimensional precision injection for facial rejuvenation. VISIA skin detector was used for skin monitoring before, during and after treatment. Clinical efficacy was evaluated by clinicians and treatment satisfaction was evaluated by patients. Results: After treatment, texture, wrinkles and brown spots detected by VISIA were significantly improved compared with those before treatment, with statistical significance (P<0.05). The total effective rate of facial contour and skin texture improvement evaluated by clinician was 98.8% and 91.67%. Patients reported the self-satisfaction of facial contour, skin quality and postoperative complications was 97.6%, 95.2% and 90.5%, respectively. Conclusion: E-D-D-L four-dimensional positioning precision injection has significant aesthetic effect in facial rejuvenation without obvious side effects, which is worthy of clinical promotion.


[1] Coleman, S. R., Rajiv, G. The anatomy of the aging face: volume loss and changes in 3-dimensional topography [J]. Aesthetic Surgery Journal (1_Supplement): S4-S9.

[2] Saleh, D. B., N. Brierley, Riaz, M., et al. (2021). “R” face and neck lift: a modified technique for en- bloc facial rejuvenation [J]. Plastic and Aesthetic Research, 2021.

[3] Bonan, P., Verdelli, A., Pieri, L., et al. (2021). Facial rejuvenation: A safe and effective treatment with a fractional non-ablative 675nm laser in Asian population [J]. Journal of Cosmetic Dermatology, 2021, 20.

[4] Kim, T. S., Kim, S. S., Jeong, C., et al. (2021). Expert consensus on the facial rejuvenation using the Mint Lift in Koreans: Perspectives of plastic surgeons [J]. Journal of Cosmetic Dermatology, 2021.

[5] H. Cui, H. Zhao, H. Xu, et al. (2021). An Innovative Approach for Facial Rejuvenation and Contouring Injections in Asian Patients [J]. Aesthetic Surgery Journal Open Forum, 2021, 3(2).

[6] Robati, R. M., Hamedani, B., Namazi, N., et al. (2020). Efficacy of microneedling versus fractional Er: YAG laser in facial rejuvenation [J]. Journal of Cosmetic Dermatology, 2020, 19(1).

[7] Schultz, K. P., Raghuram, A., Davis, M. J., et al. (2020). Fat Grafting for Facial Rejuvenation [J]. Seminars in Plastic Surgery, 2020, 34(1): 030-037.

[8] Xiu-Qi, L. I., Wang, J. Q. (2014). Advances in the Anatomic Study of Facial Retaining Ligament [J]. Medical Recapitulate, 2014.

[9] Cong, L. Y., Duan, J., Luo, C. E., et al. (2020). Injectable Filler Technique for Face Lifting Based on Dissection of True Facial Ligaments [J]. Aesthetic Surgery Journal, 2020.

[10] Matthias, Gierloff, Christine, et al. (2012). Aging changes of the midfacial fat compartments: a computed tomographic study [J]. Plastic and reconstructive surgery, 2012.

[11] Fisher, G. J., Kang, S., Varani, J., et al. (2002). Mechanisms of Photoaging and Chronological Skin Aging [J]. Archives of Dermatology, 2002, 138(11).

[12] Kim, B. J., Chang, K. H., Rhu, K. H., et al. (2009). Microneedle roller for the treatment of acne scar [J]. Journal of the American Academy of Dermatology, 2009, 60(3): AB15.

[13] Zhang, J. J., Zhu, Q. G., Zhang, L. C. (2013). Effect of different density microneedle-roller on transdermal delivery of triamcinolone acetonide [J]. Journal of Pharmaceutical Practice, 2013.

[14] Kim, J. H., Shim, S. E., Kim, J. Y., et al. (2020). A Literature Review of the Microneedle Therapy System for Hair Loss [J]. Journal of Acupuncture Research, 2020, 37(4): 203-208.

[15] Aly, N., Benoit, E., Chaubard, J. L., et al. (2022). Cosmetic Potential of a Recombinant 50 kDa Protein [J]. Cosmetics, 2022, 9(1): 8.

[16] Millar-Hume, L. (2020). Collagen stimulants in facial rejuvenation: a systematic review [J]. Journal of Aesthetic Nursing, 2020, 9(8): 334-339.

[17] Maia, R., Silva, R., Farias, S., et al. (2021). Effect of Microneedling Associated With Drug Delivery on Facial Rejuvenation: Clinical and Histological Evaluation [J]. International Journal of Medical Science and Clinical Invention, 2021, 8(4): 5349-5358.

[18] Agustin, E. W., Tassabila, D., Nisa, Z. A., et al. (2022). Collagen face spray: facial moisturizer from chicken egg shell membrane to prevent premature aging [J]. IOP Conference Series: Earth and Environmental Science, 2022, 969(1): 012008 (5pp).

[19] Melo, F. D., Carrijo, A., Hong, K., et al. (2020). Minimally Invasive Aesthetic Treatment of the Face and Neck Using Combinations of a PCL-Based Collagen Stimulator, PLLA/PLGA Suspension Sutures, and Cross-Linked Hyaluronic Acid [J]. Clinical, Cosmetic and Investigational Dermatology, 2020, 13.

How to cite this paper

Application of E-D-D-L Four-Dimensional Positioning Precise Injection Technique in Facial Rejuvenation

How to cite this paper: Yi Cao. (2022) Application of E-D-D-L Four-Dimensional Positioning Precise Injection Technique in Facial Rejuvenation. International Journal of Clinical and Experimental Medicine Research6(3), 252-256.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.07.004

Volumes & Issues

Free HPG Newsletters

Add your e-mail address to receive free newsletters from Hill Publishing Group.

Contact us

Hill Publishing Group

8825 53rd Ave

Elmhurst, NY 11373, USA

E-mail: contact@hillpublisher.com

Copyright © 2019 Hill Publishing Group Inc. All Rights Reserved.